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Dimensions: 5370 x 3580 px | 45.5 x 30.3 cm | 17.9 x 11.9 inches | 300dpi Date taken: 3 September 2022 Location: Europe More information: Kyiv, Ukraine - September 03, 2022: A pack of Winston Blue cigarettes closeup on white

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Data pre-processing Raw data were subjected to baseline filtering, peak identification, integration, retention time correction, peak alignment, and normalization using Progenesis QI 10 version 2.3 (Waters Corporation, Milford, MA, USA) 11

Indeed, two separate cohorts of young users of ENDS described reduced endothelium-dependent vasodilation and decreased nitric oxide bioavailability when compared to non-users [127, 128]